This application is a continuation of U.S. application Ser. No. 10/939,995 filed Sep. 14, 2004, now abandoned which is a continuation of U.S. application Ser. No. 09/838,544 filed Apr. 20, 2001, now U.S. Pat. No. 6,887,256, which is a continuation-in-part of U.S. application Ser. No. 09/188,472 filed Nov. 9, 1998, now U.S. Pat. No. 6,336,934, which claim benefit to Irish Patent Application No. 970789 filed on Nov. 7, 1997, Irish Patent Application No. 980267 filed on Apr. 8, 1998, International Application No. PCT/IE00/00045 filed on Apr. 20, 2000; Irish Patent Application No. 2001/0258 filed on Mar. 16, 2001; Irish Patent Application No. 2001/0260 filed on Mar. 16, 2001; and Irish Patent Application No. 2001/0261 filed on Mar. 16, 2001; all of the disclosures of which are hereby incorporated by reference in their entirety.